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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
45 Results for "
Dryopteris championii (Benth.) C. Chr.
" in MedChemExpress (MCE) Product Catalog:
Products (45)
45 Results for "Dryopteris championii (Benth.) C. Chr." in MCE Product Catalog:
8
Category:
Flavanonols Flavonoids Leguminosae Phenols Polyphenols Bauhinia championii (Benth.) Benth. Plants Disease Research Fields Inflammation/Immunology
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8 Publications Verification
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CHR-6494 is a potent inhibitor of haspin, with an IC50 of 2 nM. CHR-6494 inhibits histone H3T3 phosphorylation. CHR-6494 can be used in the research of cancer .
7
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Flavonoids Leguminosae Pueraria lobate (Willd.) Ohwi Plants Disease Research Fields Inflammation/Immunology Cancer Isoflavones
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Tosedostat (CHR-2797) is an orally active aminopeptidase inhibitor. CHR-2797 exerts antiproliferative effects against a range of tumor cell lines .
4
4 Cited Publications
Cat. No.: HY-N0772
CAS No.: 24699-16-9
3
Nanatinostat (CHR-3996) is a potent, class I selective and orally active HDAC inhibitor with IC50s of 3 nM, 4 nM, and 7 nM for HDAC1, HDAC2, and HDAC3, respectively. Nanatinostat has low activity against HDAC5 (IC50 of 200 nM) and HDAC6 (IC50 of 2100 nM). Nanatinostat induces apoptosis in myeloma cells. Nanatinostat has potent anticancer effects, such as myeloma, advanced solid tumours and colorectal cancer .
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TCRS-417 (T417) is a small-molecular inhibitor for PBX1. TCRS-417 can directly block PBX1-binding to DNA (IC50 = 6.58 μM), and affects PBX1 transcription. TCRS-417 is able to hammer out the stemness traits of Carboplatin (HY-17393)-resistant (CR) cells to revert to a differentiated status through tacking PBX1 signaling cascade. TCRS-417 significantly suppresses self-renewal and proliferation of cancer cells expressing high levels of PBX1. TCRS-417 can decrease the mRNA levels of FOXM1, NEK2, and E2F2 in cancer cell lines. TCRS-417 is selectively toxic against chr1q-amp myeloma and solid tumor cells .
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Tefinostat (CHR-2845) is a monocyte/macrophage targeted histone deacetylase (HDAC) inhibitor. Tefinostat can be cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Tefinostat can be used for the research of leukaemias .
Cat. No.: HY-19772
CAS No.: 1018673-42-1
Synonyms: ESM-HDAC391; CHR-5154; HDAC-IN-3
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GSK3117391 (ESM-HDAC391; CHR-5154; HDAC-IN-3) is an orally active HDAC inhibitor with a IC50 of 55 nM. Using esterase-sensitive motif technology, GSK3117391 is selectively converted into its active acid metabolite HDAC189 in cells expressing carboxylesterase-1. GSK3117391 induces sustained global protein acetylation in monocytes, inhibits the production of proinflammatory cytokines, depletes circulating monocytes, downregulates the expression of CSF1R, and inhibits monocyte adhesion and differentiation. GSK3117391 can be used in the research of chronic inflammatory diseases .
Cat. No.: HY-N2138
CAS No.: 152580-79-5
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Triterpenes Prosopis juliflora (Sw.) DC. Labiatae Dipsacaceae Terpenoids Dipsacus asper Wall. Plants Disease Research Fields Inflammation/Immunology
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Cat. No.: HY-N4031
CAS No.: 82375-29-9
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Cat. No.: HY-W540600
CAS No.: 53850-34-3
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Marantaceae Thaumatococcus daniellii (Benn.) Benth. Natural Products Other Diseases Plants Disease Research Fields Sweeteners Food Research
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Cat. No.: HY-126771
CAS No.: 82196-88-1
Synonyms: Chr-A
Chrysomycin A (Chr-A), an antibiotic, can be obtained from Streptomyces. Chrysomycin A exhibits antitumor and anti-tuberculous and MRSA activities. As for glioblastoma, Chrysomycin A inhibits the proliferation, migration, and invasion of cancer cells through the Akt/GSK-3β/β-catenin signaling pathway .
Cat. No.: HY-110350
CAS No.: 1458630-17-5
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CHR-6494 TFA is a potent inhibitor of haspin, with an IC50 of 2 nM. CHR-6494 TFA inhibits histone H3T3 phosphorylation. CHR-6494 TFA induces the apoptosis of cancer cells, including melanoma and breast cancer. CHR-6494 TFA can be used in the research of cancer .
Cat. No.: HY-N7591
CAS No.: 1393922-01-4
Category:
Flavonoids Chalcones Leguminosae Millettia pachycarpa Benth. Plants Disease Research Fields Cancer
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Cat. No.: HY-W193398
CAS No.: 62141-38-2
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N-2-Cyclohexylethyl-N-methylamine is an amine from A.ridigula Benth for a reduction of monoamine oxidase (MAO) activity .
Category:
Quinones other families Monophenols Anthraquinones Phenols Plants Disease Research Fields Inflammation/Immunology
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
